Therapeutic Observation of Octreotide in Treatment of Malignant Bowel Obstruction

Objective:To investigate the effect of octreotide in treatment of malignant bowel obstruction.Methods:Forty-eight patients with malignant bowel obstruction without surgical indication were randomly divided into an octreotide group(n=25) and a control group(n=23).The two groups were treated with traditional treatment of fasting,gastrointestinal decompression,supplementing fluid and correcting water electrolysis balance.Based on the traditional treatment,the octreotide group was injected octreotide 0.2 mg hypodermically(once every 6 h or 8 h) for 3 to 14 days continually.Results:The symptom remission rate in the octreotide group was 80%,the average anal exhaust time was 4.7 days and the incidence of side effect was 12 %.The symptom remission rate in the control group was 27%,the average anal exhaust time was 7 days and the incidence of side effect was 43.5%.Conclusion:The effect of octreotide is content in treatment of malignant bowel obstruction and it could reverse bowel obstruction in the early stage of malignant bowel obstruction.