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Relationship between expression of VEGF-C and lymph node metastasis in human esophageal squamous carcinoma

Yongdong Chen

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Abstract

Objective:To explore the expression of VEGF-C in human esophageal squamous carcinoma and its relationship with lymph node metastasis.Methods:The expression of VEGF-C in 49 specimens of esophageal squamous carcinoma and normal tissues were detected by immunohistochemistry.Results: The positive rates of VEGF-C were 71.4%(35/49) and 12.2%(6/49) in esophageal squamous carcinoma and normal tissue(P0.05) respectively.The expression of VEGF-C was significantly higher in cases with lymph node metastasis 73.3%(22/30) than in those without lymph node metastasis 32.6%(6/19),(P0.05).Conclusion: There is an overexpression of VEGF-C in esophageal squamous carcinoma tissues.Which may correlate with lymph node metastasis.The expression of VEGF-C might be used as a useful marker of lymph node metastasis in esophageal squamous carcinoma.

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Objective:To explore the expression of VEGF-C in human esophageal squamous carcinoma and its relationship with lymph node metastasis.Methods:The expression of VEGF-C in 49 specimens of esophageal squamous carcinoma and normal tissues were detected by immunohistochemistry.Results: The positive rates of VEGF-C were 71.4%(35/49) and 12.2%(6/49) in esophageal squamous carcinoma and normal tissue(P0.05) respectively.The expression of VEGF-C was significantly higher in cases with lymph node metastasis 73.3%(22/30) than in those without lymph node metastasis 32.6%(6/19),(P0.05).Conclusion: There is an overexpression of VEGF-C in esophageal squamous carcinoma tissues.Which may correlate with lymph node metastasis.The expression of VEGF-C might be used as a useful marker of lymph node metastasis in esophageal squamous carcinoma.

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Available abstract

Objective:To explore the expression of VEGF-C in human esophageal squamous carcinoma and its relationship with lymph node metastasis.Methods:The expression of VEGF-C in 49 specimens of esophageal squamous carcinoma and normal tissues were detected by immunohistochemistry.Results: The positive rates of VEGF-C were 71.4%(35/49) and 12.2%(6/49) in esophageal squamous carcinoma and normal tissue(P0.05) respectively.The expression of VEGF-C was significantly higher in cases with lymph node metastasis 73.3%(22/30) than in those without lymph node metastasis 32.6%(6/19),(P0.05).Conclusion: There is an overexpression of VEGF-C in esophageal squamous carcinoma tissues.Which may correlate with lymph node metastasis.The expression of VEGF-C might be used as a useful marker of lymph node metastasis in esophageal squamous carcinoma.

Key concepts: Lymph node metastasis, Immunohistochemistry, Squamous carcinoma, Esophageal Neoplasm, Medicine, VEGF receptors, Esophageal squamous cell carcinoma, Metastasis

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