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Expression of VEGF-C and CD44v6 in esophageal squamous cell carcinoma and their relation with lymph node metastasis

Yi Wang

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Abstract

Objective To investigate expression of VEGF-C and CD44v6 in esophageal squamous cell carcinoma(ESCC)and their relation with lymph node metastasis.Methods Immunohistochemistry was used to detect the expression of VEGF-C and CD44v6 protein in 152 cases of esophageal squamous cell carcinoma.Results The expression rates of VEGF-C and CD44v6 protein were 55.3% and 71.7% respectirely.And there was significant difference between lymph node metastasis group and no lymph node metastasis group(P0.05).Conclusions The expressions of VEGF-C and CD44v6 proteins in ESCC is closely related with the lymph node metastasis of ESCC.They could be used as an index to evaluate the prognosis.

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What this paper is about

Objective To investigate expression of VEGF-C and CD44v6 in esophageal squamous cell carcinoma(ESCC)and their relation with lymph node metastasis.Methods Immunohistochemistry was used to detect the expression of VEGF-C and CD44v6 protein in 152 cases of esophageal squamous cell carcinoma.Results The expression rates of VEGF-C and CD44v6 protein were 55.3% and 71.7% respectirely.And there was significant difference between lymph node metastasis group and no lymph node metastasis group(P0.05).Conclusions The expressions of VEGF-C and CD44v6 proteins in ESCC is closely related with the lymph node metastasis of ESCC.They could be used as an index to evaluate the prognosis.

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Available abstract

Objective To investigate expression of VEGF-C and CD44v6 in esophageal squamous cell carcinoma(ESCC)and their relation with lymph node metastasis.Methods Immunohistochemistry was used to detect the expression of VEGF-C and CD44v6 protein in 152 cases of esophageal squamous cell carcinoma.Results The expression rates of VEGF-C and CD44v6 protein were 55.3% and 71.7% respectirely.And there was significant difference between lymph node metastasis group and no lymph node metastasis group(P0.05).Conclusions The expressions of VEGF-C and CD44v6 proteins in ESCC is closely related with the lymph node metastasis of ESCC.They could be used as an index to evaluate the prognosis.

Key concepts: Medicine, Immunohistochemistry, VEGF receptors, Lymph node metastasis, Esophageal squamous cell carcinoma, Metastasis, Cell, Esophageal Neoplasm

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