2010•The Practical Journal of CancerRequires access

Study on The Expression of VEGF-C and its Correlation with The Clinicopathological Factors in Esophageal Squamous Cell Carcinoma

Jie-sheng Yang

Abstract

Objective To study the expression of VEGF-C in the tissues from the esophageal squamous cell carcinoma and analyze its correlation with the clinicopathological factors.Methods The expression of VEGF-C was detected by immunohistochemial staining in the tissues from 173 patients with esophageal squamous cell carcinoma.Restults The positive expression rate of VEGF-C in esophageal squamous cell carcinoma tissues was 83.24%.No significant correlation was found between the VEGF-C expression and age,sex,blood type,tumor diameter,location,tumor gross type,infiltration depth,and histological grade of the esophageal squamous cell carcinoma (P0.05).There was a significant correlation between VEGF-C expression and lymph node metastasis as well as pathological stage(P0.01).Conclusion There is high expression of VEGF-C in esophageal squamous cell carcinoma,and it play an important role in lymph node metastasis of esophageal squamous cell carcinoma.

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Key concepts: Esophageal squamous cell carcinoma, Pathological, Esophageal Neoplasm, Immunohistochemistry, Pathology, Lymph node metastasis, Medicine, VEGF receptors