Studies on pharmacokinetics and bioavailability of danofloxacin in chickens

The pharmacokinetic characteristics and bioavailability of danofloxacin following intravenous and oral administration were investigated in 125 healthy chickens by using the (High performance liquid chromatography, HPLC) interal method. The data were analyzed with the pharmacokinetic computer program MCPKP. The pharmacokinetic characteristics in the chickens following single intravenous and oral administration (5mg/kg) were best described by two compartment open model and one compartment open model with first order absorption, respectively. The main pharmacokinetic parameters intravenously were as follows: t 1/2α =0.3313 h?t 1/2β =5.9940 h?V d=7.5246 L/kg?AUC=5.6916 (μg/ml)·h?CL B= 0.8935 L/mg·h. The primary pharmacokinetic parameters of oral administration were showen below: t 1/2Ka =0.3029 h?t 1/2K =6.5128 h?t max =1.2100 h?C max =0.5159 μg/ml?AUC=5.1329 (μg/ml)·h. The bioavailability was 90.18%.