Pharmacokinetics and bioavailability of cefquinome in pigs.

The pharmacokinetics of cefquinome and the bioavailability were investigated by a cross-over design following single intravenous(1 mg/kg) and intramuscular(1 mg/kg) administration of the drug in 10 healthy pigs.A 7-day washout period was allowed between different treatments.The concentrations of cefquinome in serum were determined by HPLC and the concentration-time data were analyzed with 3P97 program.It's best to fit the cefquinome concentration-time data to two-compartment open model after single i.v.dosing.The main pharmacokinetic parameters were as follows:t1/2α 0.16 h,t1/2β 1.34 h,V(c) 0.24 L·kg-1,Cl(s) 0.26 L·kg-1·h-1,AUC 3.97 mg· L-1·h.A two-compartment model with first order absorption best described the drug concentration-time data after single i.m.administration in healthy pigs.The main pharmacokinetic parameters were as follows:t1/2ka 0.08 h,t1/2α 0.84 h,t1/2β 2.76 h,t(peak) 0.32 h,C(max) 1.80 mg·L-1,Cl(s) 0.25 L·kg-1·h-1,AUC 4.12 mg·L-1·h,F 102.37%.