Pharmacokinetics and Bioavailability of Sparfloxacin in Experimentally Induced E.coli-Mycoplasma Ill Chickens

A single dose(5mg·kg~(-1)) of sparfloxacin was given to experimentally induced E.coli-MG chickens by oral and intravenous injection.The drug concentration in plasma was detected with HPLC and the pharmacokinetics parameters were analyzed with MCPKP.The results showed that the blood concentration-time curves after oral administration were best described by a two compartment open model with first-order absorption rate.The main pharmacokinetic parameters were as follows: t_(1/2)α 1.7208h,t_(1/2)β13.1773h,t_(max) 0.9083h,C_(max) 0.6198(g·mL~(-1),AUC 3.9161mg·L~(-1)·h~(-1).After intravenous administration,the plasma concentration-time data of sparfloxacin in ill chickens was fitted to a two compartment open model without absorption,and the main pharmacokinetic parameters were as follows: t_(1/2)α 0.4442h,t_(1/2)β 4.7557h,AUC 8.3274mg·L~(-1)·h~(-1).Kel 0.5608h~(-1),V_d 4.1204L·Kg~(-1),AUC 8.3274mg·L~(-1)·h~(-1),Cl_B 0.6004L·Kg~(-1)·h~(-1).The oral bioavailability of sparfloxacin in the ill model chickens was 47.03%.