Pharmacokinetic of enrofloxacin lactate soluble powder in chickens

The pharmacokinetics and bioavailability of enrofloxacin lactate were investigated in 24 healthy Suqin yellow chickens following single intravenous and oral(10 mg/kg b.w.) administration.The concentrations of enrofloxacin lactate were determined by high-performance liquid chromatography(HPLC) and the plasma concentration-time data was analyzed by the pharmacokinetic computer program 3p87.Following intravenous administration,the drug concentration-time data was best described by a two-compartment open model.The main pharmacokinetic parameters of enrofloxacin lactate were: t1/2α(0.45±0.16) h,t1/2β(7.02±1.42) h,CL(s)(0.38±0.10) mg/kg/h,AUC(23.69±5.56)(mg/L) ×h.The drug concentration-time data was best described by a two-compartment open model after oral administration with t1/2ka(0.60±0.01)h,t1/2ke(8.25±1.73)h,tpeak(2.44±0.17) h,Cmax(1.44±0.30) mg/L,AUC(20.74±3.80)(mg/L) ×h,F 87.54%.The results showed that the pharmacokinetic characteristics of enrofloxacin lactate in healthy Suqin yellow chickens manifested with the rapid absorption,wide distribution and slow elimination.The bioavailability was high by the oral routes.