The expression and significance of PI3K p110β in progression of colorectal cancer

Objective To explore the expression of PI3K p110β in normal colorectal tissue,colorectal hyperplastic ployp,colorectal adenoma and primary colorectal carcinoma,and to investigate its significance in the progression of colorectal cancer. Methods The expression of PI3K p110β was detected in 145 specimens including normal colorectal tissue,colorectal hyperplastic ployp,colorectal adenoma and primary colorectal carcinoma by immunohistochemical staining(SP method), the relationship between the expression of PI3K p110β protein and the clinical pathological factors was analyzed. Results The positive expression rate of PI3K p110β was increased gradually in normal colorectal tissue,colorectal hyperplastic ployp,colorectal adenoma and primary colorectal carcinoma(P0.05).The expression of PI3K p110β was related to Dukes'stage,but not related to the degree of the tumor differentiation,gender or patient age. Conclusion Abnormal expression of PI3K p110β is found in the progression of colorectal cancer and the high expression of PI3K p110β was related to the development,nvasion and metastasis of colorectal cancer.