E2F3 expression in human colorectal carcinoma and adenoma and its significance

Objective:To study the expression and clinical significance of E2F3 in human colorectal carcinoma,colorectal adenoma and normal tissue.Methods:Immunohistochemistry was used to detect the E2F3 expression in 40 cases of human colorectal carcinoma tissue,20 cases of colorectal adenoma tissue and 20 cases of normal colorectal tissue.Results:The positive expression rate of E2F3 in the colorectal carcinoma tissue was 57.5%.The positive expression rate of E2F3 in the colorectal adenoma tissue was 30%.The positive expression rate of E2F3 in the normal colorectal tissue was 0.There was a significant difference in the positive expression rate of E2F3 between the colorectal carcinoma tissue and colorectal adenoma tissue(P0.05) and between the adenoma tissue and normal tissue (P0.01).The E2F3 expression in the colorectal carcinoma tissue was negatively correlated with its differentiation grade,but the E2F3 expression in the colorectal carcinoma tissue was positively correlated with the lymph node metastasis,the depth of invasion and the Dukes stage.Conclusion:The E2F3 overexpression is correlated with the occurrence and development of colorectal carcinoma.