Clinicopathological study on S100A4 expression in colorectal adenoma and colorectal carcinoma

Objective To investigate the expression of S100A4 protein in colorectal adenoma and colorectal carcinoma and its clinicopathological significance.Methods S-P immunohistochemical method was used to detect the expression of S100A4 in 51 cases of colorectal adenoma,87 cases of colorectal carcinoma and 87 cases of adjacent colorectal tissues.Results There was negative expression of S100A4 protein in glandular epithelium of adjacent colorectal tissues.The positive expression rate of S100A4 was 11.8%(6/51) in colorectal adenoma and 64.4%(56/87) in colorectal carcinoma.Compared with that in colorectal carcinoma and adjacent group,S100A4 protein expression in colorectal adenoma was significantly increased(P0.01).The expression of S100A4 was positively correlated with the clinical stages,lymph node metastasis and five-year survival(P0.05),but not with other clinicopathological factors(P0.05).Conclusion Expression of S100A4 may be associated with carcinogenesis and malignant progression of colorectal carcinoma.