Application of liquid based cytology in screening cervical cancer and precancerous lesions

Objective To investigate the application of Thinprep cytology test(TCT) screening for cervical cancer and precancerous lesions and its accuracy.Methods To conduct the retrospective analysis on 3 859 cases of TCT from January to June in 2008 in our hospital.All the cases of squamous epithelial lesions diagnosed cytologically using TBS standard including squamous cell-cannot exclude HSIL(ASC-H),low-grade intraepithelial lesion(LSIL) and above lesions accepted routine colposcopy and biopsy.The TCT results were compared with the biopsy results.Results There were 40(1.04%) cases with ASC-H,48(1.24%) cases of LSIL,31 cases(CIN Ⅱ 25 cases and CIN Ⅲ 6 cases,accounting for 0.65% and 0.16% respectively) of high-grade squamous intraepithelial lesion(HSIL) and 2(0.05%) cases of squamous cell carcinoma(SCC) in 3 895 cases of TCT,which coincidence rate with biopsy was 82.5%,70.8%,90.3% and 100% respectively.In the statistical analysis,the coincidence rate of TCT diagnosis of HSIL and above lesions to pathological biopsy by colposcopy was higher than that of LSIL with statistical difference(P0.05).In age distribution,the cytology-positive patients were mainly 31-40 year old group,accounting for 43.2%.Conclusion TCT technology combined with TBS classification standard is reliabe for screening cervical cancer and precancerous lesions,with high accuracy especially to HSIL and above lesions.It is necessary to screen cervical cancer and precancerous lesions for child-bearing women,particularly women of 31-40 years old group.