Clinical significance of liquid-based Thinprep Cytology Test and TBS for cervical diseases screening

OBJECTIVE To investigate the differences between the Thinprep Cytology Test (TCT) and pathological results, and to evaluate the accuracy of TCT for cervical lesions screening in clinic. METHODS All 800 cases cytologic screening were analyzed retrospectively. 510 cases of 800 cases cytologic screening were received by biopsies. The results of TCT were compared with that of biopsy. RESULTS Among the 800 cases, there were 484 cases (60.5%, 484 / 800) of NLIM, 316 cases (39.5%, 316 / 800) of abnormal epithelial cells, which included 8 cases of ASC-US, 32 cases of ASC-H, 15 cases of AGUS, 118 cases of HSIL, 136 cases of LSIL, 5 cases of SCC, 2 cases of AC. The positive rate of lesions up to LSIL was 51.18 % (261 / 510) in TCT and 56.47% (288 / 510) in biopsy. There was no significant difference between them (χ2 = 2.88, P﹥0.05). The coincidence rate of LSIL was 80.88%, HSIL was 93.22%, SCC was 80.0% and AC was 100%. CONCLUSION The liquid - based TCT is a vital method for cervical cancer screening, which can be adopted combined with biopsy to detect precancerous lesions of uterine cervix. TCT is an effective and perfect method for the cervical cancer screening and treatment.