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2006•Chinese Clinical OncologyRequires access

Expression and significance of PTEN in cervical squamous carcinoma

Pan Yong-qua

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Abstract

Objective:To investigate the expression and significance of PTEN protein in cervical squamous carcinoma. Methods:The SP immunohistochemical method was used to detect the expression of PTEN in 81 cases with cervical squamous carcinoma and 10 cases with normal cervical tissues. Results:There was expression in normal cervical tissues. The positive expression rate of PTEN was 55.6%(45/81) in cervical squamous carcinoma. There was significant difference between cervical squamous carcinoma and normal group(P0.05) .The expression of PTEN was also negatively-correlated with the clinical stages and the differentiation of tumor (P0.05). Conclusion:The unwonted-expression of PTEN might be an important predictor of the clinicopathologic feature of cervical cancer.

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What this paper is about

Objective:To investigate the expression and significance of PTEN protein in cervical squamous carcinoma. Methods:The SP immunohistochemical method was used to detect the expression of PTEN in 81 cases with cervical squamous carcinoma and 10 cases with normal cervical tissues. Results:There was expression in normal cervical tissues. The positive expression rate of PTEN was 55.6%(45/81) in cervical squamous carcinoma. There was significant difference between cervical squamous carcinoma and normal group(P0.05) .The expression of PTEN was also negatively-correlated with the clinical stages and the differentiation of tumor (P0.05). Conclusion:The unwonted-expression of PTEN might be an important predictor of the clinicopathologic feature of cervical cancer.

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Available abstract

Objective:To investigate the expression and significance of PTEN protein in cervical squamous carcinoma. Methods:The SP immunohistochemical method was used to detect the expression of PTEN in 81 cases with cervical squamous carcinoma and 10 cases with normal cervical tissues. Results:There was expression in normal cervical tissues. The positive expression rate of PTEN was 55.6%(45/81) in cervical squamous carcinoma. There was significant difference between cervical squamous carcinoma and normal group(P0.05) .The expression of PTEN was also negatively-correlated with the clinical stages and the differentiation of tumor (P0.05). Conclusion:The unwonted-expression of PTEN might be an important predictor of the clinicopathologic feature of cervical cancer.

Key concepts: PTEN, Medicine, Immunohistochemistry, Cervical cancer, Squamous carcinoma, Cervical carcinoma, Clinical significance, Carcinoma

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