Expression of Survivin protein and its relationship with expresion of PTEN protein in human early gastric cancer

OBJECTIVE:To explore the expression of Survivin in early gastric carcinoma and its relation with the expression of PTEN gene.METHODS:The immunohistochemical technique SP method was used to detect the expressions of Survivin and PTEN in 35 cases of normal gastric mucosa,20 cases of incomplete-type intestinal metaplasia,93 cases of mild,moderate and severe atypical nyperplasia,and 54 cases of early gastric carcinoma.RESULTS:The Survivin expression was not found in the normal gastric mucosa(0/30).The expression of Survivin gene was detected in incomplete-type intestinal metaplasia(5.00%,1/20).The positive rates of Survivin expression were 6.25%(2/32),8.57%(3/35),65.73%(17/26)in mild,moderate,severe atypical nyperplasia,respectively,and 68.51%(37/54)in early gastric carcinoma.The expresion rate of Survivin was negatively correlated with that of PTEN protein r=-0.564,P=0.0000.CONCLUSION:The abnormal expression of Survivin might play an important role in the onset and progression of early gastric carcinoma and there is a potential correlation between Survivin and PTEN expressions.