Efficacy of microbioecologics in hepatic cirrhosis patients with spontaneous bacterial peritonitis

Objective To explore the clinical effect of microbioecologics in hepatic cirrhosis patients with spontaneous bacterial peritonitis( SBP). Methods 85 cases of liver cirrhosis patients with SBP were randomly divided into treatment group( 45 cases) and control group( 40 cases). The two groups received the third generation cephalosporins and quinolones for anti-infection empirically; Treatment group was additionally given Peifeikang capsule and oral lactulose on the basis of above treatment; the course of therapy was two weeks. Results The total effecacy rate of treatment group( 80. 0%) was higher than that of control group( 55. 0%)( P 0. 05). Compared with control group,the times of disappearance of abdominal distension,abdominal pain and abdominal tenderness as well as the times of recovery of temperature and ascites leukocytes in treatment group were less( P 0. 01); AST and ALT were lower; albumin( ALB) and prothrombin activity( PTA) were higher( P 0. 05 or P 0. 01); alpha-α( TNF-α), Interleukin-6( IL-6) and endotoxin levels decreased while IL-2 and IL-10 increased( P 0. 01). The incidence rates of hepatic encephalopathy( HE) and hepatorenal syndrome( HRS) in treatment group were 8. 9% and 2. 2% respectively,lower than those in control group( 27. 5% and 17. 5%)( P 0. 05). Treatment group had no fungal infection,while control group had 3 cases. There was no significant difference in mortality rate between the two groups( P 0. 05). Conclusion Microbioecologics can regulate intestinal flora imbalance,reduce the production of intestinal endotoxin,downregulate the expression of inflammatory cytokines,and alleviate liver pathological damage. It has an auxiliary treatment effect on liver cirrhosis complicated with SBP.