Clinical study of thymic peptide combined with antibiotics in treatment of liver cirrhosis with spontaneous bacterial peritonitis

Objectiv To investigate the clinical efficacy of thymic peptide combined with antibiotics in the treatment of liver cirrhosis with spontaneous bacterial peritonitis.Methods 72 patients of liver cirrhosis with spontaneous bacterial peritonitis were randomly divided into treatment group(n=36) and control group(n=36).The patients in the control group were treated by conventional treatment,while those in the treatment group were treated by thymic peptide α1,1.6mg,injected subcutaneously once per two days on the basis of conventional treatment.The treatment duration lasted one month for both the groups.Clinical symptoms and signs of changes,ascites practices and culture results were observed before and after treatment.Results The total effective rate of treatment group(80.6%) was significantly different compared to the total effective rate of control group(52.8%)(P0.05);The mortality rate of treatment group(8.3%) was significantly lower than that of control group(19.4%)(P0.05);The time of clinical symptoms,signs,ascites practices,culture results return to normal in treatment group was significantly shorter than the control group(P0.05).Conclusion Thymic peptide combined with antibiotics in the treatment of liver cirrhosis with spontaneous bacterial peritonitis could significantly regulate the immune function of patients,improve the rates of treatment and survival.