2006•Chongqing Yike Daxue xuebaoRequires access
Expression and significance of LRP and GST-πin the testis germ cell tumor
Luo Xiao-ji
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Abstract
Objective: To investigate the expression of LRP,GST-πin the testicular germ cell tumor and evaluate their role in multidrug resistance of the testicular germ cell tumor.Methods: 41 samples of germ cell tumor without chemotherapy were analyzed immunohistochemically.Results: The total positive percentage of LRP in the testicular germ cell tumor was 41.5%,the frequence of LRP expression in Ⅰ stage,Ⅱ+Ⅲ stage,seminoma and non-seminoma germ cell tumor was 23.1%,73.3%,40.0% and 45.5% respectively.There was significant difference of the LRP expression between I stage and Ⅱ+Ⅲ stage in the testis germ cell tumor(P0.05).The total positive percentage of the expression of GST-π was 34.1%;the frequence of LRP expression in I stage,Ⅱ+Ⅲstage,seminoma and non-seminoma germ cell tumor was 38.5%,26.7%,30.0%and 45.5% respectively.The expression of GST-πwas not associated with clinical stage and pathological types(P0.05).Conclusion: The expression of LRP was correlational with the clinical stage of the testicular germ cell tumor,and LRP expression may be an important prediction of patients with testicular germ cell tumor.【