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[Survivin expression in ovarian germ cell tumors].

Rutie Yin, Zhilan Peng, Kaixuan Yang, De-ying Kang

Abstract

OBJECTIVE: To investigate the relationship between the expression of survivin and the development of ovarian germ cell tumors (OGCT). METHODS: Survivin expressions in normal ovaries (n = 10) and ovarian germ cell tumors (n = 29) were detected with labelled streptavidin biotin method. RESULTS: No survivin protein was expressed in normal ovaries. Survivin protein was found in the cytoplasm and/or the nuclear of cells of 58.6% (17/29) of the ovarian germ cell tumor samples (P < 0.05). There was no significant correlations between surviving protein and the pathologic types, stage, lymphonode metastasis, AFP and volume of ascites of the tumors (P > 0.05). CONCLUSION: High expression of survivin protein may trigger the pathogenesis of the ovarian germ cell tumors.

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Key concepts: Survivin, Germ cell tumors, Germ cell, Cancer research, Metastasis, Biology, Cell, Cytoplasm