Clinical Observation of Liuwei Nengxiao Capsules in the Treatment of Obesity and Constipation in Young Patients

OBJECTIVE:To observe the clinical efficacy and safety of Liuwei nengxiao capsule in the treatment of obesity in young patients with constipation.METHODS:82 patients were randomly divided into 2 groups.Treatment group were treated with Liuwei nengxiao capsule (2 capsules,tid) for 4 weeks (n=42),and control group were treated with compound glutamine enteric-coated capsules (2 capsules,tid) for 4 weeks (n=40).All patients were given proper guidance to diet,bowel habits,psychological status,lifestyle,etc.And relevant indicators were determined before and after treatment.RESULTS:The total effective rates were 76.19% for treatment group and 27.50% for control group,there was significant difference in clinical efficacy between 2 groups (P0.01).Serum total cholesterol,low-density lipoprotein and triglyceride were significantly decreased and high-density lipoprotein was significantly increased in treatment group,there was significant difference between 2 groups (P0.01).The improvement of abdominal pain and bloating resulting from constipation in treatment group were superior to in control group,there was statistical significance (P0.01).There was no significant difference between 2 groups before and after treatment in respects of blood count,electrolytes,liver and kidney function (P0.05).CONCLUSION:Liuwei nengxiao capsules shows good effects on regulating blood lipid and bowel function in young obesity patients with constipation,and it has sound safety and tolerance.