Expression of HER-2,ER and PR in the Breast Cancer and It's Significance

Objective To study the expression and clinical significance of HER-2,ER and PR in breast cancer.Method Immunohistochemistry method was used to analyze the expression of HER-2,ER and PR in 253 cases of breast cancers.Results Positive expression rates of HER-2,ER and PR in 253 cases of breast cancers were 41.1%,39.5% and 41.9% respectively.In 89 cases of breast cancers with the lymph node metastasis,the positive rates of expression of HER-2,ER and PR were 79.8%、29.2% and 31.5% respectively.The expression of HER-2 was positive related to lymph node metastasis,but negative related to differentiation of breast cancer.The expression of ER and PR was negative related to lymph node metastasis,but positive related to differentiation of breast cancer.Conclusion Expression of HER-2,ER and PR are involved mainly in breast carcinogenesis and they are associated with prognosis of breast cancer.Measurement of HER-2,ER and PR in the breast cancers can be used to evaluate prognosis and guide clinical treatment.