Expression of MDR、C-erbB-2、ER and PR protein in the breast cancer and clinical significance

Objective To study the expression of P170、C-erbB-2、ER and PR in breast cancer and to evaluate their clinical significances.Methods Immunohistochemistry method was used to analyze the expression of P170、C-erbB-2、ER and PR in breast cancer.Results Positive expressions of P170、C-erbB-2、ER and PR in breast cancer were 32 5%、35%、62 5% and 30%respectively.P170 expression was positive relation to chemotherapy before surgery and lymph node metastasis,and it was not connection with the expression of ER and PR.Positive expression of C-erbB-2 was positive related to lymph node metastasis,and was negative related to ER and PR expression.The expression of ER and PR were negative connection with differentiation of breast cancer and lymph node metastasis.Conclusion Expression of P170、C-erbB-2、ER and PR are involved mainly in breast carcinogenesis and they are associated with prognosis of breast cancer.P170、ER and PR are in favor to direct therapy.