Expression of ER,PR,P53,HER-2 and TOPII in 120 cases with breast cancer and it's clinical significance

Objective:To study the expression of the estrogen receptor(ER),progesterone receptor(PR),p53protein,HER-2,and topoisomerase Ⅱ(TOPⅡ) in 120 cases with breast cancer and its clinical significance.Methods:The specimens obtained from 120 cases of breast cancer were stained by immuno-histochemical methods for ER,PR,P53,HER-2,and TOPⅡ.Results:The rate of ER,PR,P53,HER-2,and TOPⅡ expression were 48(40.00%),50(42.67%),71(59.17%),67(55.83%),and 69(57.50%).There was a positive correlation between the expression of P53 and HER-2;There was a negative correlation between the expression of P53,HER-2,and ER,PR.(P0.05),clinical stages of the tumor and lymph node metastasis had a negative correlation with ER,PR,and P53.HER-2 had a positive correlation with clinical stages of the tumor and lymph node metastasis(P0.05).Conclusion:HER-2 and TOPⅡ are important prognosis factors for breast cancer patients.Combined detection of ER,PR,P53,HER-2,and TOPⅡ may play a certain role in the clinical treatment and prognostic judgement of breast cancer patients.