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2015•Journal of Hubei University of Chinese MedicineRequires access

Studies of Yiweifang Decoction on Gastric Mucosal Protection

Li L

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Abstract

Objective To investigate the protective effect of Yiweifang( YWF) decoction on gastric mucosa. Method( 1) By means of HCL- ethanol gavage in rats,the index of gastric mucosa injury was evaluated. Meantime the content of malondialdydehyde( MDA) and Glutathione peroxidase( GSH- PX) in gastric mucosa were measured.( 2) The chronic gastric gastritis models were induced by deoxycholate and ethanol. The cotent of hexosamine( HEX) and nitric oxide( NO) in gastric mucosa were measured. Also the hisopathological changes were oberserved. Results( 1) YWF decoction could inhibit the gastric mucosa injury induced by HCL- enthanol,decrease the content of MDA in gastric mucosa and promote the content of GSH- PX in gastric mucosa.( 2) YWF could improve the hisopathological state of chronic gastric gastritis models. The lever of HEX was increased,and the lever of NO was rudused in gastric mucosa. Conclusion YWF decoction possesses the protective effect on gastric mucosa.

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What this paper is about

Objective To investigate the protective effect of Yiweifang( YWF) decoction on gastric mucosa. Method( 1) By means of HCL- ethanol gavage in rats,the index of gastric mucosa injury was evaluated. Meantime the content of malondialdydehyde( MDA) and Glutathione peroxidase( GSH- PX) in gastric mucosa were measured.( 2) The chronic gastric gastritis models were induced by deoxycholate and ethanol. The cotent of hexosamine( HEX) and nitric oxide( NO) in gastric mucosa were measured. Also the hisopathological changes were oberserved. Results( 1) YWF decoction could inhibit the gastric mucosa injury induced by HCL- enthanol,decrease the content of MDA in gastric mucosa and promote the content of GSH- PX in gastric mucosa.( 2) YWF could improve the hisopathological state of chronic gastric gastritis models. The lever of HEX was increased,and the lever of NO was rudused in gastric mucosa. Conclusion YWF decoction possesses the protective effect on gastric mucosa.

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Available abstract

Objective To investigate the protective effect of Yiweifang( YWF) decoction on gastric mucosa. Method( 1) By means of HCL- ethanol gavage in rats,the index of gastric mucosa injury was evaluated. Meantime the content of malondialdydehyde( MDA) and Glutathione peroxidase( GSH- PX) in gastric mucosa were measured.( 2) The chronic gastric gastritis models were induced by deoxycholate and ethanol. The cotent of hexosamine( HEX) and nitric oxide( NO) in gastric mucosa were measured. Also the hisopathological changes were oberserved. Results( 1) YWF decoction could inhibit the gastric mucosa injury induced by HCL- enthanol,decrease the content of MDA in gastric mucosa and promote the content of GSH- PX in gastric mucosa.( 2) YWF could improve the hisopathological state of chronic gastric gastritis models. The lever of HEX was increased,and the lever of NO was rudused in gastric mucosa. Conclusion YWF decoction possesses the protective effect on gastric mucosa.

Key concepts: Gastric mucosa, Decoction, Glutathione, Gastritis, Chemistry, Gastroenterology, Stomach, Medicine

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