Experimental Research of LOSEC on Gastric Mucosa Protection Function and Mechanism of Gastric Ulcer Big Rats

Objective:Explore the molecular mechanism of lose treatment on gastric ulcer.Methods:Copying and pyloric ligation induced gastric ulcer rat model,continuous medicine for five days.Respectively,measure the ulcer index,gastric mucosa activity and gastric acid,CGRP content,EGF distribution and EGFR expression.Results:Losec can significantly reduce gastric acid-ethanol rats of gastric mucosa ulcer index(P0.01),yet gastric mucosal GSH content and GSH-PX activity had no significant influence(P0.05).Losec can significantly reduce pyloric ligation induced gastric ulcer rat(P0.01),restrain gastric acid,total amount,free acidity and total acids from abnormal increased(P0.01),increase gastric mucosa CGRP content and distribution of EGF(P0.010),but no significant effect of EGFR expression(P0.05).Conclusion:The resistance mechanism on gastric acid-ethanol may have nothing to do with free radical scavenging of GSH and GSH-PX.The mechanism of antioxidant pyloric ligation may have relationship with its strong effect of inducing Gastric acid secretion,increasing gastric mucosa CGRP content and EGF distribution,but with no relevance to gastric mucosa EGFR expression.