2002•WeichangbingxueRequires access
Protective Effects of Antioxidants on Gastric Mucosa
Jinjin Liu
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Abstract
Aims: To study the protective effects of antioxidants on gastric mucosa of mice and of the patients with gastric ulcer. Methods: The model was constructed by ethanol administration orally in mice. Salis-buria adiantifolia preparation was administered as antioxidant to protect the gastric mucosa. The levels of lipoperoxidant (LPO) in the gastric mucosa and the blood were determined. Selenocarrageen was given to patients with gastric ulcer. The levels of LPO in the mucosa were determined before and after the administration and compared with that of the controls. Results: Both LPO levels in gastric mucosa and blood of mice were significantly lower in Salisburia adiantifolia group than those in the ethanol model group (P0.05 in the mucosa; P0.01 in the blood). The decrease of LPO was more significant in the mucosa of gastric ulcer patients of Selenocarrageen group compared with that of the controls (P 0.001). Conclusions: Antioxidants Salisburia adiantifolia preparation and Selenocarrageen can protect the gastric mucosa from damages caused by oxygen free radicals in both mice and gastric ulcer patients.