Analysis of Drug Resistance of 546 Common Clinical Pathogens

Objective To investigate the drug resistance of 546 common pathogens to provide the basis for the treatment of the infectious diseases. Methods From April to September 2012, 546 common pathogens isolated from clinical specimens species were analyzed. The identification and susceptibility testing were performed by VITEK 2 compact system(BioMerieux, France). Results Among 546 strains of the pathogen, Gram-negative bacteria were predominant(82.8%). Escherichia coli ranked the first place(22.2%), followed by Acinetobacter baumanii/haemolylicus(16.5%)and Klebsiella pneumonia(15.4%). Among Gram-negative bacteria except Strenotrophomonas maltrophilia, the drug resistance of imipenem and ertapenem was the lowest, followed by amikacin and piperacillin/tazobactam. Resistant rate of Ampicillin to Baumanii, Klebsiella pneumoniae and Pseudomonas aeruginosa was more than 95%. The drug resistance of Staphylococcus aureus was lower than that of coagulase negative Staphylococcus. Methicillin resistant Staphylococcus aureus(MRSA) was 22.00%, while Methicillin resistant coagulase negative Staphylococcus(MRCNS) was 94.44%.Furthermore, Staphylococcus aureus and coagulase negative Staphylococcus strains were sensitive to vacomacin, linezolid,tigecycline, quinupristin/dalfopristin and furantoin. Conclusions Among clinical common pathogens, the preponderant strain was Gram-negative bacteria. Among Gram-negative bacteria except Strenotrophomonas maltrophilia, the drug resistance of imipenem and ertapenem is the lowest. The drug resistance of Staphylococcus aureus is lower than that of coagulase negative Staphylococcus. As yet, there was no vancomycin resistant Staphylococcus strains in our new school district hospital.