Therapeutic effect of trimebutine maleate in treating type 2diabetes mellitus patients with diarrhea and effect on gastrointestinal motility

Objective To observe the clinical therapeutic effect of trimebutine maleate in treating type 2diabetes mellitus(T2DM)patients with diarrhea and the changes of gastrointestinal motility.Methods Fifty-two T2DM patients with diarrhea were randomly divided into group A(25cases)and group B(27cases)by digital table method.On the basement of hypoglycemic therapy,patients in group A were given anti-diarrhea treatment,and those in group B were treated with trimebutine maleate,and the clinical efficacy was evaluated after treatment for 12weeks.Another 10cases of T2DM patients without diarrhea were selected as control group(group C).The oral-colon transit time(OCTT)as a gastrointestinal dynamic evaluation index was detected by hydrogen breath test.The changes of plasma somatostatin(SS),motilin(MTL)and gastrin(GAS)levels were measured by using radioimmunoassay.Results ①The total effective rate of group A and group B were 68.0%and 92.6%,and group B was better than group A(P 0.05).②There was no statistic difference of OCTT before treatment between group A and group B(76.3±18.9)min vs(76.6±20.7)min(P 0.05),but each of them was significantly lower than that of group C(106.9±8.5)min(P 0.01).After treatment,the OCTT in group A and group B was(86.8±16.1)min and(99±11.2)min,respectively,which were longer than before treatment(P 0.01),and the OCTT in group B was significantly longer than that of group A(P 0.01).③Before treatment,the levels of plasma MTL and GAS of group A and B were significantly higher than those in group C(P 0.01),and the SS level was lower than that in group C(P 0.01);After treatment,the levels of SS,MTL and GAS of two groups were significantly improved as compared with before treatment,and the changes of group B were more obvious(P 0.01).Conclusion Trimebutine maleate has good clinical efficacy in treatment of T2DM with diarrhea,its mechanism may relate to the regulation of gastrointestinal hormone secretion,improve gastrointestinal motility disorder,and its adverse reactions was fewer and mild.