Clinical Effect of Hormone and β-Adrenoceptor Agonist on IL-8 and IL-10 Expression in Elderly Patients with Chronic Obstructive Pulmonary Disease

Objective To investigate interleukin-8(IL-8) and interleukin-10(IL-10) expression changes in elderly patients with chronic obstructive pulmonary disease(COPD) before and after treatment of hormone and β-adrenoceptor agonist and their clinical efficacy. Methods 112 patients with COPD were randomly divided into group A, group B, group C and group D, with 28 cases in each. Patients in group A were treated with conventional therapy, patients in group B were treated with Terbutaline Sulphate Solution for nebulization inhalation based on conventional therapym, patients in group C were treated with Budesonide Suspension for inhalation based on conventional therapy, and patients in group D were treated with Terbutaline Sulphate Solution and Budesonide Suspension based on the conventional therapy. The concentration of IL-8 and IL-10 in sputum and the pulmonary function indices of the four groups were compared before and after treatment. Results After treatment, the concentration of IL-8 in group A was(712.57 ± 77.69) ng/L. group B(735.17 ± 99.53) ng/L, group C(689.21 ± 97.48) ng/L, group D(599.37 ± 131.25) ng/L, which were significantly lower than those before treatment(P 0.05). And the IL-8 concentration of group D after treatment was significantly lower than the other three groups(P 0.05). After treatment, the concentration of IL-10 in group A was(31.96 ± 15.85) ng/L, group B(32.09 ± 11.53) ng/L, group C(36.39 ± 17.26) ng/L, group D(37.04 ± 15.38) ng/L. The IL-10 concentration of group C and group D after treatment were significantly higher than those before treatment(P 0.05), but the difference between the four groups after treatment was not statistically significant(P 0.05). After treatment, the FEV1% predictive value of group D was(37.94 ± 11.63), group C(37.82 ± 12.76), which were significantly higher than group A(29.68 ± 9.98) and group B(33.87± 10.07)(all P 0.05). The comparison of the remaining lung function indices among the four groups before or after treatment had no statistical significant difference(P 0.05). The FVC, FVC%, FEV1and FEV1% forecast predicted values of the four groups after treat ment were significantly higher than those before treatment, and FEV1/FVC was significantly lower than that before treatment(P 0.05). Conclusions In the inflammatory process of COPD, IL-8 and IL-10 play important roles. Hormone can increase the IL-10 concentration and reduce the IL-8 concentration. Hormone combined with β-adrenoceptor agonist has better clinical efficacy.