Application of intravenous flurbiprofen axeyil injection combined with tramadol hydrochloride for postoperative analgesia in patients underwent orthopedic surgery of lower limb

Objective:To explore the analgesic effects and side effect of intravenous postoperative anlgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride. Methods:Forty cases undergoing orthopedic surgery of lower limb were randomly divided into two groups with twenty cases each:flurbiprofen axeyil injection 100 mg+tramadol hydrochloride 1 000 mg+ondansetron hydrochloride 8 mg(A group),tramadol hydrochloride 1 200 mg+ ondansetron hydrochloride 8 mg(B group).The drugs in each group were diluted to 100ml.Analgesic pattern was background flow rate 2 ml/h with 0.5 ml self-controlled dose every time.Locking time was 15 min.The VAS score,pressing times and incidence of side effects were recorded during the period of postoperative 24 hours. Results:The VAS of group B at 8 h after operation was higher than that of group A(P0.05),while the VAS of group B at 2,4,24 h were similar as group A(P0.05).The accidence rate of nausea,vomiting in two groups were similar(P0.05).The total accidence rate of group A was lower than that of group B(P0.05).No respiratory depression or abnormal bleeding occurred in two groups. Conclusions:Intravenous postoperative analgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride has a better analgesic effect than tramadol hydrochloride alone and was a safe and effective therapy.