Preemptive analgesia with flurbiprofen axetil or tramadol before gynecologic hysteroscopic surgery:a comparison of outcome

Objective To compare the effect of preemptive analgesia with flurbiprofen axetil or tramadol before operation.Methods Sixty patients undergoing gynecological hysteroscopic surgery were randomly divided into two groups,including tramadol group and flurbiprofen group with 30 cases in each group.Two groups of patients were all induced with remifentanil and propofol,intubated with laryngeal mask and implemented by a program of total intravenous anesthesia.Five minutes before anesthesia,two groups were injected with flurbiprofen axetil 100 mg or tramadol 100 mg,respectively.Time of postoperation recovery,visual analog seale(VAS)at each time point and adverse events were recorded.Results VAS was Maximum at 0.5 h after operation,descended gradually 1 h after operation.VAS at 2 h,6 h,12 h after operation were significantly lower than that at 0.5 h after operation(P0.05).VAS between two groups had no statistically difference at each time point.Time of postoperation recovery between two groups had no statistical difference(P0.05).The incidence of postoperative nausea and vomitting(PONV)in tramadol group was significantly higher than that in flurbiprofen group(30.0% vs 10.0%,P0.05),the incidence of sore throat in tramadol group was significantly higher than that in flurbiprofen group(20.0% vs 6.7%,P0.05).Conclusion Compared with tramadol,preemptive analgesia with flurbiprofen was effective equally,and had lower incidence of PONV and sore throat.