2008•Zhongguo laonianxue zazhiRequires access
The effect of TTM on anti-oxidase and lipase peroxide in brain tissues of Alzheimer disease rats induced by okadiac acid
Huang Li
Open publisher page 0 citations
Abstract
Objective To observe the effect of trillium tschonoskii maxim(TTM) on anti-oxidase and lipase peroxide(LPO) expression in gyrus hippocampi and cerebral cortex of Alzheimer disease(AD) rats model.Methods AD model rats were made by injection okadiac acid(OA) via lateral ventricles.Positive control group were given TTM and vitmin C by peritoneal injection.The contents of SOD,GSH-Px,MDA in gyrus hippocampi and cerebral cortex of normal,model,positive control and experimental groups were determined.Results Compared normal group,model group had the reduced SOD and GSH-Px(P0.01 or P0.05),and the increased MDA(P0.001).Compared with positive control group,experimental group had significant difference in SOD,GSH-Px and MDA between high and moderate dose group(P0.05),but had obvious or had no obvious difference between low dose group(P0.05 or P0.05).Conclusions TTM delaying aging might be associated with the increased SOD,GSH-Px activity and reduced MDA,in brain tissues.