Anti-oxigenated effect of codonopsis pilosula(Enshi) on Alzheimer disease of rat induced by okadaic acid

Objective To observe the effect of codonopsis pilosula(Enshi) on expression of oxygen free-radical and tau protein in gyrus hippocampi and cerebral cortex of rats with Alzheimer disease induced by okadaic acid.Methods The rat model of Alzheimer disease induced by okadaic acid was employed.Positive control and test group were injected with Vit.C.Codonopsis pilosula(Enshi) groups and control group's supreoxide dismutase(SOD),glutathione peroxidase(GSH-PX),malondialdehyde(MDA) and tau protein in gyrus hippocampi and cerebral cortex were measured.Results In contrast with control groups,concentrations of SOD(114.98±22.90),GSH-PX(13.11±1.78)and SOD(159.94±14.67),GSH-PX(12.25±1.47) in cerebral cortex and gyrus hippocampi of rats with Alzheimer disease were lower(P0.05,0.001).Concentrations of MDA(5.38±2.76),Tau(174.97±12.89) and MDA(4.81±1.54),Tau(148.61±10.77)in cerebral cortex and gyrus hippocampi of model rats were higher than that of control group(P0.001).Concentrations of SOD,GSH-PX,MDA and tau protein showed statistically significant difference between high(750?mg) and moderate dose(500?mg) model group(P0.05),and the difference between lower dose group(250?mg) and model group was not signifieant(P0.05).Conclusion Codonopsis pilosula(Enshi) can up-regulate expression of SOD,GSH-PX and down-regulate expression of MDA and tau protein in brain tissues of experimental rats.