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2010•Kunming Yike Daxue xuebaoRequires access

The Content Determination of Paeono in DANQI Granula by HPLC

Jie Zhang

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Abstract

Objective To establish an HPLC method for determining the content of paeonol in DANQI granula,and provide a certificate for the quality control of the product.Methods The determination was performed by RP-HPLC on Agilent TC-C18 (4.6 ×250 mm,5 μm) with mobile phase consisted of methanol-water (60:40) at a flow rate of 1.0 mL/min.The detection wavelength was set at 274 nm.Results The linear range of paeonol was 20.0～320.0 μg/mL (r = 0.9998).The recovery was 98.19% (RSD=0.67%,n=6).Conclusion The HPLC method is simple,accurate and well reproduced for the determination of paeono for quality control of DANQI granula.

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What this paper is about

Objective To establish an HPLC method for determining the content of paeonol in DANQI granula,and provide a certificate for the quality control of the product.Methods The determination was performed by RP-HPLC on Agilent TC-C18 (4.6 ×250 mm,5 μm) with mobile phase consisted of methanol-water (60:40) at a flow rate of 1.0 mL/min.The detection wavelength was set at 274 nm.Results The linear range of paeonol was 20.0～320.0 μg/mL (r = 0.9998).The recovery was 98.19% (RSD=0.67%,n=6).Conclusion The HPLC method is simple,accurate and well reproduced for the determination of paeono for quality control of DANQI granula.

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Available abstract

Objective To establish an HPLC method for determining the content of paeonol in DANQI granula,and provide a certificate for the quality control of the product.Methods The determination was performed by RP-HPLC on Agilent TC-C18 (4.6 ×250 mm,5 μm) with mobile phase consisted of methanol-water (60:40) at a flow rate of 1.0 mL/min.The detection wavelength was set at 274 nm.Results The linear range of paeonol was 20.0～320.0 μg/mL (r = 0.9998).The recovery was 98.19% (RSD=0.67%,n=6).Conclusion The HPLC method is simple,accurate and well reproduced for the determination of paeono for quality control of DANQI granula.

Key concepts: Paeonol, Chromatography, High-performance liquid chromatography, Content determination, Chemistry, Linear range, Detection limit, Medicine

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