Clinical Observation on Curative Effect of Sitagliptin, Rosiglitazone Combined with Metformin Respectively in Treatment of Elderly Type 2 Diabetes

Objective: To observe and compare the clinical efficacy between sitagliptin and the rosiglitazone combined with metformin respectively on the treatment of type 2 diabetes in elder patients.Methods:70 admitted cases from Apr.2010 to Oct.2012 were randomized into A(n=36) B(n=34)group single blindly,group A was given sitagliptin plus metformin schme,and group B was applied with rosiglitazone plus metformin schme,both were treated for 12 weeks,After which blood glucose level,clinical efficacy and adverse drug reaction during treatment were noted and compared between 2 groups.Results: ①Glycemic indexes of 2 group patients after 12 weeks' therapy were lower than pre-treatment(P 0.05),2hPG level of group A was significantly lower than that of group B(P 0.05).②Patients in group A with significant efficiency(50%),overall efficiency(91.7%) was slightly higher than that of group B(38.2%,85.3%),the difference was not statistically significant(P0.05).③There were no seriously adverse drug reactions in 2 groups,incidences of adverse reactions of 2 groups(19.4%vs.26.5%) showed no significant difference(P0.05).Conclusion: Both 2 schemes are effective in treatment of elderly patients with type 2 diabetes mellitus,sitagliptin plus metformin scheme compared with rosiglitazone plus metformin scheme has a comparative advantage in clinical efficacy,and especially has obvious advantage in reducing postprandial blood glucose.