The Effect Observation of Metformin Combined with Sitagliptin in Treatment of Early Type 2 Diabetes Mellitus

Objective To observe curative effect of metformin combined with sitagliptin in treatment of early type 2 diabetes mellitus.Methods From November 2008 to November 2012 in our hospital treated 160 cases of early type 2 diabetic patients,which were randomly divided into study group and control group,the study group using metformin and sitagliptin treatment,control group with single metformin treatment,compared two groups of patients before and after treatment,2 months,4 months of glycemic control and adverse reaction.Results The two groups before treatment,fasting blood glucose(FBG),2h postprandial plasma glucose(2hPBG) and glycosylated hemoglobin(HbA1c),there was no significant difference(P 0.05);treatment of 2 months and 4 months after the index,the study group than in the control group,the difference was statistically significant(P 0.05);the study group and the control group in the treatment of adverse reaction incidence rates were 7.5% and 8.8%,the difference between the two groups was not statistically significant(P 0.05).Conclusion Metformin combined with sitagliptin treatment of type 2 diabetes curative effect,less adverse reaction,is worth the clinical promotion.