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2008•Chinese Journal of Birth Health & HeredityRequires access

Research on expression and significance of Integrinβ3 and TGF-β_1 in placenta of patients with hypertensive disorder complicating pregnancy

Yongmei Guan

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Abstract

Objective:Study on the expression of integrinβ3 and transforming growth factor-β(TGF-β1) in the plaenta tissues in order to evaluate the role of them approach their correlation in the course of hypertensive disorder complicating pregnancy.Methods:Immunohistochemical method was used to detect the expression of integrinβ3 and TGF-β1 in the placenta tissues in 12 cases hypertensive disorder complicating pregnancy and 13 cases normal pregnancies.Results:The expression of integrinβ3 and TGF-β1 of hypertensive disorder complicating pregnancy group was significantly higher than those of normal pregnancies(P0.01).Conclusion:The increased expression of integrinβ3 and TGF-β1 might be involved in the pathogenesis of hypertensive disorder complicating pregnancy.

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What this paper is about

Objective:Study on the expression of integrinβ3 and transforming growth factor-β(TGF-β1) in the plaenta tissues in order to evaluate the role of them approach their correlation in the course of hypertensive disorder complicating pregnancy.Methods:Immunohistochemical method was used to detect the expression of integrinβ3 and TGF-β1 in the placenta tissues in 12 cases hypertensive disorder complicating pregnancy and 13 cases normal pregnancies.Results:The expression of integrinβ3 and TGF-β1 of hypertensive disorder complicating pregnancy group was significantly higher than those of normal pregnancies(P0.01).Conclusion:The increased expression of integrinβ3 and TGF-β1 might be involved in the pathogenesis of hypertensive disorder complicating pregnancy.

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Available abstract

Objective:Study on the expression of integrinβ3 and transforming growth factor-β(TGF-β1) in the plaenta tissues in order to evaluate the role of them approach their correlation in the course of hypertensive disorder complicating pregnancy.Methods:Immunohistochemical method was used to detect the expression of integrinβ3 and TGF-β1 in the placenta tissues in 12 cases hypertensive disorder complicating pregnancy and 13 cases normal pregnancies.Results:The expression of integrinβ3 and TGF-β1 of hypertensive disorder complicating pregnancy group was significantly higher than those of normal pregnancies(P0.01).Conclusion:The increased expression of integrinβ3 and TGF-β1 might be involved in the pathogenesis of hypertensive disorder complicating pregnancy.

Key concepts: Hypertensive disorder, Pregnancy, Pathogenesis, Placenta, Medicine, Transforming growth factor, Immunohistochemistry, Integrin

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