The expression of matrix metalloproteinases-8 in placenta of hypertensive disorder complicating pregnancy

Objective To investigate the expression of matrix metalloproteinases-8(MMP-8)in placenta of hypertensive disorder complicating pregnancy and approach its role in the course of hypertensive disorder complicating pregnancy.Methods MMP-8 of placenta was determined by immunohistochemical SABC assay and compared between 67 case hypertensive disorder complicating preg nancies and 21 case normal pregnancies.Results The positive rate of MMP-8 in normal pregnancies was 80.9%,which is significantly higher than that in hypertensive disorder complicating pregnancy(26.9%),P0.05.Accompanying the aggravation of pathogenetic condition,the positive rate of MMP-8 in hypertensive disorder complicating pregnancy had a decreased tendency.Conclusion The expression of MMP-8 in hypertensive disorder complicating pregnancy decreased significantly and had a decreased tendency accompanying the aggravation of pathogenetic condition,which indicated that MMP-8 has a close relation with the development of hypertensive disorder complicating pregnancy.