The clinical value of the plasma brain natriuretic peptide for the patients with acute coronary syndrome

Objective:To investigate the value of brain natriuretic peptide (BNP) in the evaluation of degree of coronary artery disease and heart function in patients with acute coronary syndrome(ACS).Method:Eighty-one patients with ACS were divided into two groups, one is unstable angina patients(n=39), the other is acute myocardial infarction(n=42). The relationship between the level of plasma BNP and degree of coronary artery lesion, as well as left ventricular ejection fraction (LVEF), were analyzed.Result:The level of plasma BNP elevated with the aggravation of degree of coronary artery lesion, and systolic cardiac dysfunction. The serum level of BNP was higher in AMI patients than in UAP. The level of increas in serum BNP concentration was positively correlated with the number of vessel in which had been found lesion on coronary angiography(rs=0.813,P0.01),but negatively with the level of LVEF(rs=-0.846,P0.01).Conclusion:Serum BNP is a useful marker for diagnosis and risk assessment of coronary artery disease and heart failure.