The diagnostic value of B-type natriuretic peptide for left ventricular dysfunction in patients with coronary heart disease

Objective To study the relationship between the plasma level of B-type natriuretic peptide(BNP) and the left ventricular function in patients with coronary heart disease. Methods BNP levels in plasma of 30 nomal controls and 69 patients with coronary heart disease were measured by chemilumino-immunoassay. The ventricular function was measured by NYHA and colored doppler echocardiography. Results The BNP concentrations in control group, ventricular function (Ⅰ-Ⅱ) group and ventricular function (Ⅲ-Ⅳ) group were (31.56±21.48) μg/L, (105.52±(91.77)) μg/L and (433.18±378.03) μg/L respectively. There was statistical significance among these groups(P(0.001). The levels of plasma BNP and the left ventricular ejective fraction (LVEF) had a significant negative correlation (r=(-0.70), P0.001). BNP levels of LVEF≤40% subgroup were significantly higher than those of LVEF40% subgroup (P0.01). Conclusions BNP level reflects the left ventricular function in patients with coronary heart disease. The determination of BNP has important value in the diagnosis of early ventricular dysfunction and the evaluation of the severity of cardiac failure.