Surveillance of bacterial resistance from Dalian Centeral Hospital in 2009

Objective To investigate the pathogenic bacteria distribution and antibiotic resistance of clinical isolates from our hospital in 2009,and povide a basis for clinical treatment.Methods Antibibtic susceptibility tests were performed according to K-B method.Results were analyzed according to CLSI 2009.and corresponding results were analyzed with WHONET 5.4 software.Results A total of 3202 clinical isolates were collected,of which Gram-negative organism,Gram-positive cocci and fungi accounted for 78.8%,15.7%and 5.5%,respectively.The ESBLs producing strains of Escherichia coli and Klebsiella pneumoniae accounted for 68.4%and 58.3%,respectively.Meticillin resistant strains of Staphylococcus aureus and coagulase negative Staphylococcus accounted for 53.6%and 61.7%,respectively.Escherichia coli and Klebsiella pneumoniae showed 100%susceptibility to carbopenems. But the susceptibility of Pseudomonas aeruginosa and Acinetobacter to carbopenems reduced to 47.7%-—71.6%.Gram-positive cocci were highly sensitive to glycopeptides and linezolid.Conclusion Bacterial resistance increased,we should monitor pathogens and resistance change timely and strengthen the rational use of antimicrobial agents.