Pathogens and drug resistance of lower respiratory tract infections in the department of respiratory medicine

OBJECTIVE To investigate distribution and drug resistance of pathogens for lower respiratory tract infections in the department of respiratory medicine and provide a reference for hospital treatment and control of lower respiratory tract infections.METHODS Sputum specimens from 70 patients with lower respiratory tract infections during Jan.2011 to Dec.2012 in the department of respiratory medicine were analyzed for pathogen detection and drug resistance with retrospective approaches.Data were analyzed with SPSS 18.0.RESULTS A total of 80 pathogens were detected from the 70 patients,mainly including gram-negative bacteria(60.0%),gram-positive bacteria(31.25%)and fungi(8.75%).The resistance rate of gram-negative bacteria to ceftazidime,ciprofloxacin,ticarcillin,and gentamicin was 90.0%~100.0%,and was the lowest to imipenem and piperacillin.The resistance rate of gram-positive bacteria to penicillin G,rifampin,gentamicin,levofloxacin,tetracycline,erythromycin,ciprofloxacin was between 66.7%~100.0% and was the lowest to vancomycin,sulfamethoxazole/trimethoprim,and linezolid.CONCLUSION Lower respiratory tract infection in the department of respiratory medicine was mainly due to gram-negative bacteria,and there is a wide range of drug resistance,clinical management of antimicrobial drugs should be strengthened to reduce the drug-resistant strains,and to improve clinical outcomes.