Distribution and Drug-resistance analysis of Pathogens from Lower Respiratory Tract Infection among Patients in Respiratory Department

OBJECTIVE To determine the distribution and drug resistance characteristic of pathogens from Patients with CAP,HAP and HCAP in Respiratory Department,and provide reference for selecting clinical antibiotics.METHODS By retrospective analysis,the distribution and drug-resistance of the patients with lower respiratory tract infection from Nov.2008 to Jun.2010 were analyzed.RESULTS Among 510 strains of pathogens,the Gram-negative bacilli(GNB)accounted for 73.14%,the major bacteria were Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli and Acinetobacter baumannii.The Gram-positive bacteria(GPB)accounted for 16.08%,the major bacteria were Staphylocouus aureus and Streptococcus pneumoniae.The fungi accounted for 10.78%,and the most predominant was C.albican.Gram-negative bacteria were susceptible to meropenem,imipenem,amikacin,piperacillin/tazobactam,gentamicin,tobramicine,cefepime and ceftazidime,and the drug resistance rate was less than 30%.Gram-positive bacteria were highly resistant to erythromycin,clindamycin,ciprofloxiacin,tetracycline and gentamicin,and the drug resistance rate was more than 60.00%.100.00% of fungi were sensitive to ketoconazole.CONCLUSION GNB was still the most important pathogens in Lower Respiratory Tract Infection and had multiple drug resistance.Bacterial culture and drug-resistance tests was very important to correctly select antibiotics.