THE EXPRESSIONS OF PSA AND PCNA IN PROSTATIC CARCINOMA AND THEIR SIGNIFICANCE

ObjectiveTo study the features of expression of PSA and PCNA in prostatic carcinoma and benign prostatic hyperplasia(BPH). MethodsThe tissues of different-grade prostatic carcinoma in 44 cases and benign BPH in 20 cases were collected and stained by immunohistochemical method. The expressions of PSA and PCNA were observed.ResultsThe expression of PSA in BPH tissue was higher (16/20) than that in prostatic carcinoma samples (23/44), the difference was significant ( H=7.535, P0.05). With the increase of Gleason scores and clinical staging, PSA expression in the carcinoma declined (H= 7.031, 7.396, P0.05). The difference between PSA expression and serum-PSA level was not significant statistically (H= 0.653,P0.05). The expression of PCNA in carcinoma tissue was significantly higher than that in the BPH tissue (H=7.892, P0.05). The expression of PCNA increased with the increase of Gleason scores (H=6.502, P0.05). The difference of expressions of PCNA in different clinical stages showed no significance (H=2.345, P0.05).ConclusionThe expression of PSA and PCNA is related to the development and progression of prostatic carcinoma. [