Expression of PCNA and P27 in Prostate Carcinoma and Its Clinical Significance

OBJECTIVE:To study the expression of PCNA and P27 protein in patients with prostate carcinoma and to study its clinical significance. METHODS: The expressions PCNA and P27 in 30 patients with hyperplasia of prostate gland and 46 with prostate carcinoma were detected by S-P immunohistochemical method. RESULTS: Strong positive expression rates of PCNA in patients with hyperplasia of prostate gland and in those with prostate carcinoma were 6.7% and 82.6%, respectively, and there were significant differences between 2 groups (P0.01). The strong positive expression of PCNA showed a negative correlation with differentiation degree of prostatic carcinoma (P0.05) but a positive correlation with its clinical stage (P0.05). Strong positive expression rates of P27 in patients with hyperplasia of prostate were 70%, and 17.4% in those with prostate carcinoma, and there were significant differences between 2 groups (P0.01). The expression of P27 showed a positive correlation with differentiation degree of prostatic carcinoma (P0.05), but a negative correlation with clinical stage (P0.05). A negative correlation was found between P27 and PCNA expressions in both hyperplasia of prostate gland and prostate carcinoma (P0.05). CONCLUSION: It is of great significance to determine P27 and PCNA for the diagnosis, malignant grading and prognostic estimation of prostate carcinoma.