The relationship between ANP gene T2238C polymorphism and essential hypertension in Xinjiang Kazakans

Objective: To investigate the relationship between ANP gene T2238C polymorphism and essential hypertension in Xinjiang Kazakans. Method:We selected 313 essential hypertensive patients whose SBP≥140 mm-Hg and/or DBP≥90 mmHg and 205 normotensive subjects whose BP140/90 mmHg of Kazakans in Xinjiang. We measured their ANP gene T2238C polymorphism by PCR-RFLP and tested the association of this polymorphism with hypertension. Result:We had got three kinds of genotypes of T2238C, The distributed frequencies of TT、TC、CC were 87. 2% ,11. 2%, 1. 6% of hypertensive patients and 91. 2% ,7. 8% ,1. 0% of controls respectively. The distributed frequencies of T and C allele were 92. 8%,7. 2% of hypertensive patients and 95. 1%,4. 9% of controls respectively. Both of genotypes and allele frequencies had no significant difference between the two groups (X2=2. 013 and X2=2. 249, P 0. 05). There was no association with 2238C and hypertension(β =-0. 371, P 0. 05). Conclusion: There were three kinds of genotypes of ANP T2238C in Kazakans of Xinjiang. The study suggested the ANP T2238C polymorphism might not be associated with essential hypertension in Kazakans.