Study for relationship between the angiotensin II type 1 receptor gene polymorphism and essential hypertension in Kazakans of Xinjiang

Objective:To investigate the relationship between the A1166C allele polymorphism of angiotensin Ⅱ type 1 receptor(AT1R) gene and the essential hypertension in Kazakans of Xinjiang.Method:Polymerase chain reaction and restriction fragment length polymorphism methods(PCR-RFLP) were used to detect the A1166C polymorphism of AT1R gene in Kazakans including 321 patients with hypertension and 203 normotensive controls.The frequencies of genotype distribution in hypertensives and normotensives were studied.Result:The genotype frequencies of A1166C were AA 0.766 4,AC 0.227 4,CC 0.006 2 in the hypertension group and the corresponding frequencies were 0.753 7,0.246 3,0,in the control group respectively;The A1166 and 1166C allele frequencies were 0.880 1,0.119 9 respectively in hypertension group and 0.876 8,0.123 2 in normotensive group.The distribution of A1166C-genotype and the allele frequencies of A1166/1166C were not statistic significances in hypertension group compared with normotensive group(P0.05).Conclusion:There was no significant association found between the A1166C polymorphism of AT1R gene and essential hypertension in Kazakans of Xinjiang.