The Relationship between Dyslipemia and Polymorphism of AT_1R Gene A1166C in Kazakans of Xinjiang

Objective To investigate the relationship between dyslipemia and polymorphism of angiotensin Ⅱ type Ⅰ receptor(AT1R) gene A1166C in Kazakans of Xinjiang.Methods Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) methods were used to detect the A1166C polymorphism of AT1R gene in Kazakans including 296 patients with hypertension and 198 normotensive controls.Biochemical indexes were detected by autochemical hemalyzer.Results The genotype frequencies of A1166C and the A1166/1166C allele frequencies were not statistic significances in hypertension group compared with normotensive group(P0.05).But the TC and LDL in hypertension group are higher than those in the normotensive group(P0.001).In hypertension group,TC and LDL are related to A1166C polymorphism of AT1R gene.TC and LDL in AC genotype group are higher than those in AA genotrpe group.Conclusions There was no significant association found between the A1166C polymorphism of AT1R gene and essential hypertension in Kazakans of Xinjiang.But the dyslipemia is related to A1166C polymorphism of AT1R gene in essential hypertension group of Kazakans.