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2010•Journal of Medical ForumRequires access

Adjunctive Therapeutic Effect of Quetiapine on Refractory Depression

Luo Cheng

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Abstract

Objective To explore the effect of venlafaxine combined with quetiapine in the treatment of refractory depression.Methods Totally 90 patients with refractory depression were randomly assigned into two groups,quetiapine combined with venlafxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the Hamilton Depressive Scale(HAMD) and the Hamilton Anxiety Scale(HAMA).Adverse effects were assessed by the Treatment Emergent Symptom Scale(TESS).Results As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6weeks'treatment(P0.01),especially for combined group(P0.01orP0.05).Conclusion The combination of quetiapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

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What this paper is about

Objective To explore the effect of venlafaxine combined with quetiapine in the treatment of refractory depression.Methods Totally 90 patients with refractory depression were randomly assigned into two groups,quetiapine combined with venlafxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the Hamilton Depressive Scale(HAMD) and the Hamilton Anxiety Scale(HAMA).Adverse effects were assessed by the Treatment Emergent Symptom Scale(TESS).Results As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6weeks'treatment(P0.01),especially for combined group(P0.01orP0.05).Conclusion The combination of quetiapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

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Available abstract

Objective To explore the effect of venlafaxine combined with quetiapine in the treatment of refractory depression.Methods Totally 90 patients with refractory depression were randomly assigned into two groups,quetiapine combined with venlafxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the Hamilton Depressive Scale(HAMD) and the Hamilton Anxiety Scale(HAMA).Adverse effects were assessed by the Treatment Emergent Symptom Scale(TESS).Results As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6weeks'treatment(P0.01),especially for combined group(P0.01orP0.05).Conclusion The combination of quetiapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

Key concepts: Quetiapine, Hamd, Venlafaxine, Refractory (planetary science), Hamilton depression scale, Depression (economics), Internal medicine, Medicine

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