Adjunctive therapeutic effect of Buspirone on refractory depression

Objective To explore the effect of venlafaxine combined with Buspirone in the effect and adverse reation refractory depression. Methods 92 patients with treatment-refractory depression were randomly assigned into two groups,buspirone combined with venlafaxine (combination group )and venlafaxine alone (single group )for 6 weeks. The clinical efficacy were evaluated by the hamilton depressive scale (HAMD) and the hamilton anxiety scale (HAMA). Adverse effects were assessed by the treatment emergent symptom scale (TESS). Results As compared with the baseline scores,the HAMD scores as well as HAMA ,the two groups decreased significantly after 6weeks'treatment (P0.01) ,especially for combined group (P0.01or P0.05). Conclusion The combination of buspirone with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.